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A sterile woman gives birth to a child from a frozen oocyte. A first !

A woman who became sterile following treatment for breast cancer was able to give birth to her first child thanks to an oocyte frozen several years ago. It is the first time that this protocol has been completed! This one, carried out in a French hospital, is described in Annals of Onoclogy.

Despite breast cancer who made her sterile, a 34-year-old French woman was able to to give birth to her first child. She followed a protocol of maturation in vitro of his oocytes, followed by vitrification of these, called IVM for " in vitro maturation ". It’s a world first since it’s the first pregnancy which comes to an end as a result of this technique. This unique case is described in Annals of Onoclogy.

Perfectly preserved oocytes for 5 years

At the announcement of his carcinoma ductal invasive on the left breast, the 29-year-old patient, who had never been pregnant, undergoes a fertility Review. At 16e day of her cycle, doctors observe by to scan at ultrasound 17 small follicles from Graaf that contain ovules still immature. The taking ofhormone to stimulate the maturation of eggs is contraindicated in the case of this patient. She then chooses the IVM technique.

On day 22 of her cycle, the doctors take 7 immature eggs. It is in the laboratory that the latter will continue their evolution, in an environment composed of serum of the patient as well asfollicle stimulating hormone and gonadotropin. Two days after treatment, six of the seven oocytes are in metaphase II. At this stage, they are mature and are only waiting for the fertilization by the sperm to become eggs diploid and form a zygote.

To keep the precious cells, doctors used the vitrification method. It is an ultra-rapid freezing technique where the temperature decreases by -20 ° C every minute which allows less damage to the cells. Vitrified oocytes are stored at -196 ° C in nitrogen liquid.

Five years later, the patient conquered her cancer but has suffered from reproductive disorders for a year. The team then decides to take the precious oocytes out of their dormant state. The six survived the IVM protocol! Doctors have them fertilized in vitro by cytoplasmic sperm injection. Following fertilization, the oocytes continued to transform into five viable zygotes. One of them was transferred to theuterus of the patient and little Jules was born in July 2019.

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