innovative nanometric particle imaging technology

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Myriade, deep tech that develops and markets an innovative nanometric particle imaging technology, has launched a new innovative optical device: the Videodrop. Discovery.

Resulting from the work of the Langevin Institute, a French academic laboratory specializing in optical and ultrasonic technologies for the life sciences, the technology of Videodrop is based on a single-arm interferometry technique. This technology allows live nanopSmart health articles such as viruses, phages, or Extracellular Vesicles (FVEV) to be viewed without labeling.

The innovation lies in the transformation of a standard microscope into a simplified (called single-arm) interferometer. The Videodrop films all objects between 30 nm and 10 µm in real time and without marking, in a single drop of solution (5-10 µL). Videodrop processing algorithms measure the concentration and size distribution of nanopSmart health articles from the film. We can therefore observe, on the same image, viruses and aggregates, phages and bacteria, Extracellular Vesicles and cells.

After a validation phase by 5 teams working in the fields of production of viral vectors for immunotherapy, production of phages aimed at replacing antibiotics, diagnosis of inflammatory bowel disease by counting phages of the microbiota , the production of Extracellular Vesicles to replace viruses as a vector, and the characterization of infectious viruses, Videodrop is launched commercially and could become a new reference tool for the control of biological nanopSmart health articles.

" At a time when the medical world is moving strongly in favor of cellular and gene therapies – treatments consisting in introducing genetic material into the patient's cells to correct a genetic defect or to modify them to fight a disease – the Videodrop will allow quickly and efficiently control the concentration of virus in injectable doses and the possible presence of impurities for better safety for the patient. Indeed, the optical technology of the Videodrop makes it possible to see in real time the viruses, whose diameter is a few tens of nanometers while they are invisible for conventional microscopy techniques. The Videodrop is the ideal system to control these complex solutions containing viruses all along the bioproduction chain ”Explains Luc Talini, Managing Director of MYRIADE, the company that develops and markets the Videodrop.

Among the technologies which make it possible to detect viruses, that of Videodrop remains the only one which allows a simple assay, without marking and in real time.

How was Videodrop born?

The Videodrop technology was born from the Tara Oceans expedition, whose mission is to take samples of seawater all over the world to study the impact of global warming on planktonic and coral systems. Martine Boccara, virologist at IBENS, was in charge of the inventory of the virus population in seawater samples. Martine was looking for a simple and robust virus counting method to lead to well its experiments, the standard methods used proving too cumbersome or difficult to master. She then spoke to her brother, Claude Boccara, a professor at the Langevin Institute and a great French specialist in optical interferometry technologies, who then designed the interferometric microscope at the basis of Videodrop technology.

Source: Myriade

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