How NAD+ Could benefits For Your Skin Care?

September 26, 2022

NAD skincare (NAD+) is an effective method for reversing solar and chronological aging dermal and epidermal symptoms.

NAD+'s ability to regenerate the deepest layers of skin strata and replace the skin's NAD+ pool has improved because to technological breakthroughs such as liposomal delivery.

"NAD+ is reshaping the skincare scene, and it's our most promising anti-aging method to date." — Dr. Dreama Pilcher

NAD skincare

AGE DEFYING POWER

Because of their potential to increase oxidized nicotinamide adenine dinucleotide (NAD+), NAD+ precursors like niacinamide have a long history in dermatology.

"The use of niacinamide, both systemically and topically, has been shown to be effective in the treatment of medical and cosmetic disorders."

Aging of the Skin

"As a precursor of NAD / NADP, niacinamide stimulated collagen synthesis, epidermal biopolymers (proteins), and keratin synthesis."

Healing of wounds

"The time it took for a wound to heal was reduced from 15–17 days to 7–10 days."

Anti-inflammatory

"After 8 weeks, 82 percent of individuals treated demonstrated an improvement in their overall illness state."

Hyperpigmentation

"A significant reduction in hyperpigmentation as a result of niacinamide skin lightening."

Rosacea

"There was a reduction in horny layer moisture in addition to an improvement in horny layer moisture."

UV Deterioration

"On aging skin, niacinamide enhances the skin's surface structure, has a wrinkle-smoothing effect, and inhibits photocarcinogenesis."

SHIELDS UV DAMAGE

NAD+ shortage in the skin causes UV sensitivity, DNA damage, and may contribute to wrinkles by weakening the link between the dermis and epidermis of extrinsically aged skin.

Because of its importance in the aging process, it is finding its way into dermatologists' anti-aging arsenals.

According to researchers,

"It may prevent dermal matrix deterioration by inhibiting the enzymes that break down collagen and promote an optimal physiologic environment: the stimulation of cell activity, hydration, and the creation of collagen, elastin, and HA (hyaluronic acid),"

THE GENOME IS PROTECTED

Recent scientific results have made the need of replenishing and sustaining cellular NAD+ levels mainstream.

NAD+ has been found as an essential factor in maintaining genomic integrity and has been highlighted as a key to general skin health. A genome is a full set of DNA that includes all of an organism's genes.

To resist daily genomic assaults, tissues with a high cellular turnover, such as the skin, require greater amounts of NAD+.

ELASTICITY OF THE SKIN HAS BEEN IMPROVED

Scientists are now learning that the NAD+ chemical, like niacinamide, can provide anti-aging skin health benefits such as wrinkle reduction, collagen formation, and increased skin suppleness.

MOISTURE CONTENT INCREASE

Transepidermal water loss (TEWL) is reduced and the moisture content of the stratum is improved when B3 is applied topically.

RESTORES CELL FUNCTION

Because of its key function in maintaining and restoring cellular health, there has been a lot of interest in increasing NAD+ levels in recent years.NAD+ is required for nearly 500 key metabolic operations in cells, spanning anything from energy production to preserving healthy DNA.

Researchers discovered that NAD+ levels decrease with aging in human tissue in the first investigation of its kind.

"The observation of a link between NAD+ levels and aging lends credence to the concept that NAD+ is involved in cell senescence and longevity beyond its role as an electron transporter."

REJUVENATES SKIN

The NAD+ metabolic pathway has been highlighted as a possible therapeutic target to enhance cellular health because chronic oxidative stress and chronological aging can cause NAD+ breakdown in the skin, from the outermost layer to the deepest layer. 12

Increased NAD+ levels have been found to minimize global oxidative cell damage, refill total NAD+ storage, and restore normal skin cell function in recent investigations.

Scientists claim that

"A significant cause of NAD+ depletion is the chronic accumulation of oxidative stress and inflammation in old age." The use of NAD+ precursors to promote NAD+ anabolism could be a clinically meaningful treatment method for age-related cellular energy reduction."

COMBATS INFLAMMATION

Researchers showed exceptional antipsoriatic performance of topical NAD+ in a study assessing the efficiency of topical NAD+ in 37 patients suffering from psoriasis.

"Topical NAD+ therapy can be seen as a potential alternative to traditional psoriasis treatment without the adverse effects," says the researcher.

External and internal variables such as UV exposure, stress, environmental pollutants, and the normal aging mechanisms that occur in all cells and tissues all contribute to skin aging.

Raising NAD+ levels has the potential to suppress many aging pathways at once, making it a promising approach to skin rejuvenation.

ACTIVATES LONGEVITY GENES

The sirtuins—the "guardians of the genome"—are responsible for most of the increasing attention in NAD+ over the last decade.

Sirtuins (SIRT1-SIRT7) are a family of seven proteins found in humans that are involved in a variety of cellular processes related to dermatology and can only function in the presence of NAD+.

These longevity-linked proteins are extensively implicated in photoaging, collagen production, UV radiation damage response, oxidative stress, and wound repair, and are now being discussed by everyone in the skincare sector.

Sirtuins are important regulators of cellular pathways that are linked to skin health.

NAD+ supplementation to the skin may help activate sirtuins in skin cells, reducing the harmful effects of UV exposure, DNA damage, and aging.

NAD+ LEVELS DECLINE WITH AGE NAD skincare

SKIN MAY SUPPLY NAD+ TO OTHER TISSUES

NAD+ levels in muscle tissue drop during exercise, but NADH levels increase, according to previous study. (White and Schenk, 2012) (White and Schenk, 2012) (White and Schenk,

"After moderate (75 percent of VO2max) and high intensity (100 percent of VO2max) exercise, NAD+ level in human muscles decreased."

"Exercising until you're completely exhausted changes the NAD+/NADH ratio."

In this 2019 study, NADH levels rise while NAD+ levels fall in the skin.

"Within two minutes of starting an exercise, NADH levels rise and stay increased throughout and soon after the exercise."

"At this level, skin cells have a vibrant NADH metabolism and react dynamically to ischemia-induced hypoxia and then re-oxygenation during reperfusion."(NADH was selected as a proxy because an increase in NADH causes a proportionate reduction in NAD+.)

CONCLUSION

NAD+ deficiency causes DNA strand breakage, increased reactive oxygen species (ROS), and apoptotic cell death in skin cells. NAD+ resupply can protect cells from oxidative stress, DNA damage, senescence, and tissue inflammation.

The use of NAD+ on the skin to treat age-related diseases and refill the NAD+ reservoir in the skin for usage by other cells and tissues is a clinically important treatment technique.

The efficacy of increasing skin NAD+ concentrations with pure NAD+ paves the way for future science-based product formulations.