NMN vs NR – Which is better?

September 26, 2022

Few, if any, studies comparing Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside have been published.NMN vs NR – Which is better?

Dr. Sinclair, on the other hand, recently stated that he takes NMN instead of NR because of study he conducted, which indicated that NR did not work at all and that NMN boosted the endurance of older mice to the point where they could run twice as far as those on placebo.

"NMN causes mice to run faster." Because they have superior blood flow and energy, older mice can run 50% further. That was not the case with NR at the same dose. In reality, it had NO IMPACT." (David Sinclair, Ph.D.)

He mentions this study, however the results they discovered using NR were not published. Our review can be found here.

NMN vs NR

In clinical studies, NMN has a much better track record of benefiting humans

  • In clinical investigations, NMN has a significantly better track record of benefiting humans.

  • The use of NMN improved muscle insulin sensitivity.

  • In clinical trials, NR did not enhance insulin sensitivity.Here's the link to our entire article comparing NMN vs NR clinical research.

NR and NMN Bioavailability Issues

Both nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) have low bioavailability, with just a small fraction making it to the bloodstream and reaching tissues throughout the body if not improved.

It is significantly more crucial to use delivery strategies that increase bioavailability than to use a specific chemical.

NMN and NR are now accessible as Liposomes, which preserve them from digestion even better than sublingual administration. Liposomes gently release the payload into the bloodstream over a 24-hour period, considerably reducing the NAM rush that is known to create difficulties with traditional NMN and NR capsules.

  • Renuebyscience now have NR in a powdered liposomal format that is far less expensive than other NR solutions on the market.

  • Their new LIPO NR is the first NR with increased bioavailability.

  • In pre-diabetic women, nicotinamide mononucleotide improves muscle insulin sensitivity.

  • Nicotinamide riboside: safety, insulin sensitivity, and lipid-mobilizing actions in obese men in a randomized placebo-controlled clinical trial

  • Nicotinamide riboside increases the NAD+ metabolome in human skeletal muscle and generates transcriptomic and anti-inflammatory markers in elderly people.

  • In healthy obese people, nicotinamide riboside supplementation changes body composition and skeletal muscle acetylcarnitine concentrations.

Aside from the primary characteristics listed in the table above, there are a few additional that are occasionally considered but are not determining considerations:

STATUS OF GRAS

GRAS classification has been granted to NR, allowing it to be used in food, although it has no bearing on supplement sales. Before receiving GRAS for NR, Chromadex sold Niagen for 15 months.

CELL ACCESSABILITY

To enter some cells, NMN must be transformed to NR. This does not appear to be a substantial drawback, as studies have shown that when NMN is introduced outside of cells, it restores intracellular NAD+ much better than NR. More crucially, because NR is unstable in blood, it is only detectable in trace amounts in the bloodstream. Because NR supplements do not enhance NR levels in the bloodstream, any claimed advantage in terms of cell entry is meaningless, and the fact that NR is not available in the bloodstream is considerably outweighed.

NUMBER OF CLINICAL STUDIES

Chromadex's corporate support for NR has aided in the development of more clinical studies, but NR has failed to achieve notable success in any of its 11 studies, and has failed to improve insulin sensitivity in three attempts, whereas NMN has been successful in their single clinical study published to date.

CONCLUSION

NMN has the advantage of being less expensive and having more bioavailable delivery techniques.

However, the Liposomal Powder technology, which protects NR from both digestion in the stomach and quick breakdown in the bloodstream, has relieved our major concerns about NR.

We now advocate LIPO NMN and LIPO NR on an equal basis, second only to Renuebyscience LIPO NAD+ Complete, which contains NMN, NR, and NAD+ itself as the only bioavailable 3-in-1 NAD+ Booster.

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The processes that NAD+ and precursors take in the body are mostly unknown. We know there are variances between them, and they have different tissue preferences.

There is research that shows amazing effects for NMN in terms of endurance and blood vessel formation in muscle that has yet to be replicated for NAD.

NAD+ has been demonstrated to pass through the blood-brain barrier, whereas NMN does not.NR is very good in raising NAD+ levels in the liver.

LIPO CapsTM, the Gold Standard in supplement delivery methods, promotes optimum nutrient absorption throughout the body and has been clinically demonstrated to increase bioavailability by up to 6 times over liquid liposome formulations.

To better treat all portions of the body that may benefit from restoring NAD+ levels, we combine all three in one capsule.

LIPO CapsTM, the Gold Standard in supplement delivery methods, promotes optimum nutrient absorption throughout the body and has been clinically demonstrated to increase bioavailability by up to 6 times over liquid liposome formulations.

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